(R)-(+)-2-(4-羟基苯氧基)丙酸合成路线 （共 15 条）
反应条件
sodium hydroxide; water T=25 - 30°C; 2 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: WO2006/1562 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
concentrated aqueous hydrochloric acid; acetic acid in water
参考文献
BASF Aktiengesellschaft
Patent: US5801272 A1, 1998 ;
反应条件
hydrogenchloride in water T=20°C; pH=1; Purification / work up;
参考文献
WO2005/42460 A1, ;
Page/Page column 5 ;
反应条件
1: With sodium hydroxide; sodium hydrogensulfite in water T=50 - 65°C; 4 h; 2: With phosphoric acid in water T=45°C; pH=11; 3: With sulfuric acid in water T=55°C; pH=6.5 - 7.5; Product distribution / selectivity;
参考文献
WO2005/42460 A1, ;
Page/Page column 4-5 ;
反应条件
1: With sodium hydroxide in water T=50 - 65°C; 4 h; 2: With phosphoric acid in water T=45°C; pH=11; 3: With sulfuric acid in water T=55°C; pH=6.5 - 7.5; Product distribution / selectivity;
参考文献
WO2005/42460 A1, ;
Page/Page column 5 ;
反应条件
chiral stationary phase derived from aminated silica gel, L-2-(p-toluenesulfonamido)-3-phenylpropionyl chloride and dendrimer in hexane; isopropyl alcohol T=25°C; Resolution of racemate;
参考文献
Chirality, , vol. 22, # 1 p. 69 - 76
反应条件
dihydrogen peroxide; ascorbic acid powder T=20°C; pH=7.0; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeregioselective reaction;
参考文献
Tetrahedron Letters, , vol. 49, # 41 p. 5950 - 5953
反应条件
Beauveria bassiana LU 700; medium A T=30°C; Oxidation;
参考文献
Pesticide Science, , vol. 46, # 1 p. 33 - 35
参考文献
Tosoh Corporation; Agro-Kanesho Co., Ltd.
Patent: US4948421 A1, 1990 ;
反应条件
1: 2,6-dichloro-quinoxaline; (R)-(+)-2-(4-hydroxyphenoxy)propionic acid With potassium phosphate; tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide T=50 - 60°C; 2 h; 2: With 2,4,6-trichloro-1,3,5-triazine in N,N-dimethyl-formamide T=5 - 25°C; 1.16667 h; 3: ethanol in N,N-dimethyl-formamide
参考文献
Kalhor, Mehdi; Dadras, Akbar; Mobinikhaledi, Akbar; Tajik, Hassan
Journal of the Chilean Chemical Society, 2011 , vol. 56, # 4 p. 833 - 836
