4-(2,3,4,9-四氢-1H-beta-咔啉-1-基)-1-丁醇合成路线 （共 14 条）
反应条件
1: dimethyl sulfoxide; sulfur trioxide pyridine complex; triethylamine / dichloromethane / 2 h / 0 °C
2: sodium acetate; hydroxylamine hydrochloride / isopropyl alcohol / 1.5 h / 20 °C
3: Acid orange 52; sodium cyanoborohydride; hydrogenchloride / methanol / 1 h / 20 °C
4: sodium cyanoborohydride / tert-butyl alcohol / 16 h / |Inert atmosphere; |Sealed tube; |Microwave irradiation
5: zinc; trifluoroacetic acid; water / dichloromethane / 20 °C
View Scheme
参考文献
Dion, Isabelle; Vincent-Rocan, Jean-Francois; Zhang, Lei; Cebrowski, Pamela H.; Lebrun, Marie-Eve; Pfeiffer, Jennifer Y.; Bedard, Anne-Catherine; Beauchemin, Andre M.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12735 - 12749
反应条件
1: sodium acetate; hydroxylamine hydrochloride / isopropyl alcohol / 1.5 h / 20 °C
2: Acid orange 52; sodium cyanoborohydride; hydrogenchloride / methanol / 1 h / 20 °C
3: sodium cyanoborohydride / tert-butyl alcohol / 16 h / |Inert atmosphere; |Sealed tube; |Microwave irradiation
4: zinc; trifluoroacetic acid; water / dichloromethane / 20 °C
View Scheme
参考文献
Dion, Isabelle; Vincent-Rocan, Jean-Francois; Zhang, Lei; Cebrowski, Pamela H.; Lebrun, Marie-Eve; Pfeiffer, Jennifer Y.; Bedard, Anne-Catherine; Beauchemin, Andre M.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12735 - 12749
反应条件
1: sodium cyanoborohydride / tert-butyl alcohol / 16 h / |Inert atmosphere; |Sealed tube; |Microwave irradiation
2: zinc; trifluoroacetic acid; water / dichloromethane / 20 °C
View Scheme
参考文献
Dion, Isabelle; Vincent-Rocan, Jean-Francois; Zhang, Lei; Cebrowski, Pamela H.; Lebrun, Marie-Eve; Pfeiffer, Jennifer Y.; Bedard, Anne-Catherine; Beauchemin, Andre M.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12735 - 12749
参考文献
Groves; Swan
Journal of the Chemical Society, 1952 , p. 650,658
