2-氟-6-甲氧基苯甲腈合成路线 （共 19 条）
反应条件
NaH in dimethyl sulfoxide
参考文献
Warner-Lambert Company
Patent: US5679683 A1, 1997 ;
反应条件
diisobutylaluminium hydride in hexane; toluene T=-78 - 20°C; Reduction;
参考文献
Smith III, Amos B.; Wan, Zehong
Organic Letters, 1999 , vol. 1, # 9 p. 1491 - 1494
反应条件
hydrogenchloride; methyl-magnesium iodide in diethyl ether
参考文献
Akzo Nobel
Patent: US6645973 B1, 2003 ;
反应条件
1: in tetrahydrofuran 6 h; Reflux; 2: With hydrogenchloride in water T=75°C; 20 h;
参考文献
Bryan, Marian C.; Biswas, Kaustav; Peterkin, Tanya A.N.; Rzasa, Robert M.; Arik, Leyla; Lehto, Sonya G.; Sun, Hong; Hsieh, Feng-Yin; Xu, Cen; Fremeau, Robert T.; Allen, Jennifer R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 619 - 622
反应条件
pyridine hydrochloride T=190°C; 5 h;
参考文献
BASF Aktiengesellschaft
Patent: WO2006/56433 A2, 2006 ;
Location in patent: Page/Page column 30 ;
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
参考文献
Palermo
Tetrahedron Letters, 1996 , vol. 37, # 17 p. 2885 - 2886
反应条件
methanecarbohydroxamic acid; potassium tert-butylate in DMF (N,N-dimethyl-formamide) T=20 - 60°C; 16.6667 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/39796 A1, 2004 ;
Location in patent: Page/Page column 57-58 ;
WO 2004/039796 A1
反应条件
1: potassium tert-butylate / tetrahydrofuran / 0.67 h / 95 °C / |Microwave irradiation 2: trifluoroacetic acid; hydrogenchloride / water / 0.13 h / 95 °C / |Microwave irradiation View Scheme
参考文献
Ang, Wei Jie; Chu, Chi-Yuan; Chou, Tzyy-Chao; Lo, Lee-Chiang; Lam, Yulin
Green Chemistry, 2013 , vol. 15, # 3 p. 780 - 785
反应条件
dihydrogen peroxide; potassium carbonate in dimethyl sulfoxide
T=0 - 25°C;
参考文献
Ni, Shuaishuai; Yuan, Yaxia; Huang, Jin; Mao, Xiaona; Lv, Maosheng; Zhu, Jin; Shen, Xu; Pei, Jianfeng; Lai, Luhua; Jiang, Hualiang; Li, Jian
Journal of Medicinal Chemistry, 2009 , vol. 52, # 17 p. 5295 - 5298
