(R)-(+)-2-(2-甲酯基乙基)-2-甲基环己酮合成路线 （共 13 条）
反应条件
1: 2-methyl-cyclohexanone With benzylamine in toluene T=90°C; Michael condensation; 4 h; Inert atmosphere; 2: acrylic acid methyl ester in toluene T=90°C; Michael condensation; 24 h; Inert atmosphere;
参考文献
Kang, Jun Yong; Carter, Rich G.
Organic Letters, 2012 , vol. 14, # 12 p. 3178 - 3181
反应条件
acetic acid in water T=20°C; 97 h;
参考文献
Pichette, Simon; Aubert-Nicol, Samuel; Lessard, Jean; Spino, Claude
European Journal of Organic Chemistry, 2012 , # 7 p. 1328 - 1335
反应条件
bis-(trifluoromethylsulphonyl)amine in toluene T=20°C; 1 h;
参考文献
Azuma, Takumi; Takemoto, Yoshiji; Takasu, Kiyosei
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 9 p. 1190 - 1193
反应条件
hydrogen; palladium on activated charcoal P=760 Torr;
参考文献
Journal of Organic Chemistry, , vol. 61, # 13 p. 4361 - 4368
反应条件
bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; Domino Michael addition - Claisen condensation; 1 h;
参考文献
Azuma, Takumi; Takemoto, Yoshiji; Takasu, Kiyosei
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 9 p. 1190 - 1193
反应条件
bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; Domino Michael addition - Claisen condensation; 1 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 59, # 9 p. 1190 - 1193
反应条件
bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; Domino Michael addition - Claisen condensation; 1 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 59, # 9 p. 1190 - 1193
反应条件
1: toluene-4-sulfonic acid / toluene / 3 h / Reflux 2: acetic acid / water / 97 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 1 p. 164 - 169
反应条件
bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; Flow microreactor; optical yield given as percent dediastereoselective reaction;
参考文献
Kurahashi, Kei; Takemoto, Yoshiji; Takasu, Kiyosei
ChemSusChem, 2012 , vol. 5, # 2 p. 270 - 273
反应条件
water 1.) MeOH, 4 h; 2.) heating; Yield given. Multistep reaction;
参考文献
Hickmott, Peter W.; Rae, Bruce
Tetrahedron Letters, 1985 , vol. 26, # 21 p. 2577 - 2580
