1: N-(5-Acetyl-pyridin-2-yl)-4-(3-dimethylamino-propoxy)-benzenesulfonamide With hydrogen bromide in acetic acid; N,N-dimethyl-formamide T=45°C; 2: With pyrrolidone hydrotribromide in acetic acid; N,N-dimethyl-formamide T=50°C; 1 h; 3: thiolacetic acid potassium salt With dipotassium hydrogenphosphate more than 3 stages;