1-溴-3,5-二甲基金刚烷合成路线 （共 25 条）
反应条件
bromine 12 h; Reflux;
参考文献
Ren, Huixue; Ying, Hanjie; Ouyang, Pingkai; Lin, Jimao; Jing, Liu
Asian Journal of Chemistry, 2012 , vol. 24, # 11 p. 5107 - 5110
反应条件
hydrogen bromide in water 0.666667 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 69, # 10 p. 2251 - 2259
反应条件
1: With sodium hydroxide in diethylene glycol T=105 - 170°C; 10 h; 2: With hydrogenchloride in water; toluene T=5 - 15°C; 2.5 h; Product distribution / selectivity;
参考文献
WO2008/62472 A2, ;
Page/Page column 16-17 ;
反应条件
pyridine; carbon tetrabromide; water; Mn(III) acetylacetonate Heating; Catalytic behavior; ConcentrationTemperatureTime;
参考文献
Russian Journal of Organic Chemistry, , vol. 50, # 1 p. 25 - 28
Zh. Org. Khim., , vol. 50, # 1 p. 33 - 36,4
反应条件
1: sulfuric acid / 12 h 2: sodium hydroxide / water; ethylene glycol / 12 h / 150 °C 3: hydrogenchloride / pH 6 / Gas phase View Scheme
参考文献
Ren, Huixue; Ying, Hanjie; Ouyang, Pingkai; Lin, Jimao; Jing, Liu
Asian Journal of Chemistry, 2012 , vol. 24, # 11 p. 5107 - 5110
反应条件
T=22 - 75°C; Inert atmosphere; Product distribution / selectivity;
参考文献
MERZ PHARMA GMBH andamp;; CO. KGAA; GOLD, Markus-Rene; QUACK, G;nther
Patent: WO2010/83996 A1, 2010 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: T=157°C; 14 h; 2: With water in dichloromethane T=5 - 25°C; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/122238 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;
反应条件
formamide T=155°C; 8 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/122238 A1, 2006 ;
Location in patent: Page/Page column 14-15 ;
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride T=90°C; Barton-McCombie Deoxygenation; 1 h; Inert atmosphere; Solvent;
参考文献
Kobayashi, Shoji; Kuroda, Hiroyuki; Ohtsuka, Yuta; Kashihara, Takashi; Masuyama, Araki; Watanabe, Kiyoshi
Tetrahedron, 2013 , vol. 69, # 10 p. 2251 - 2259
反应条件
in anhydrous butyl ether T=95°C;
参考文献
Canadian Journal of Chemistry, , vol. 65, p. 2428 - 2433
