2-甲基-1,3-二氧戊环-2-丙酸乙酯合成路线 （共 17 条）
反应条件
1: LiAlH4
2: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
3: LiBr / acetone / 1.) room temperature, overnight, 2.) reflux, 4 h
View Scheme
参考文献
COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian
Patent: WO2013/130654 A1, 2013 ;
反应条件
lithium aluminium tetrahydride in diethyl ether
T=25°C;
参考文献
Ameer, Farouk; Giles, Robin G.F.; Green, Ivan R.; Nagabhushana, Kyatanahalli S.
Synthetic Communications, 2002 , vol. 32, # 3 p. 369 - 380
参考文献
Willimann; Schinz
Helvetica Chimica Acta, 1949 , vol. 32, p. 2151,2159
反应条件
1: n-BuLi, HMPTA / tetrahydrofuran / 3 h / -78 °C
2: p-Toluenesulfonic acid / acetone
View Scheme
参考文献
Mussatto, Maria Cristina; Savoia, Diego; Trombini, Claudio; Umani-Ronchi, Achille
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4002 - 4005
反应条件
1: 66 percent / 1.) NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 65 °C
2: 82 percent / DBU / benzene / 15 h / Ambient temperature
3: 31 percent / HEH / RuCl2(bpy)3 / pyridine / 20 h / Ambient temperature; Irradiation
4: 2M hydrochloric acid / acetone / 5 h / Ambient temperature
View Scheme
参考文献
Mussatto, Maria Cristina; Savoia, Diego; Trombini, Claudio; Umani-Ronchi, Achille
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4002 - 4005
反应条件
1: LiAlH4
2: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
View Scheme
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
反应条件
diisobutylaluminium hydride in hexane; dichloromethane
T=-78 - 0°C; 0.5 h; Inert atmosphere;
参考文献
Ogura, Tetsuhiro; Usuki, Toyonobu
Tetrahedron, 2013 , vol. 69, # 13 p. 2807 - 2815
