8-苯基-1,4-二噁螺-4,5-8-癸醇合成路线 （共 7 条）
反应条件
1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C View Scheme
参考文献
Ekkati, Anil R.; Mandiyan, Valsan; Ravindranathan, Krishna P.; Bae, Jae H.; Schlessinger, Joseph; Jorgensen, William L.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2228 - 2231
反应条件
1: in tetrahydrofuran
T=10 - 20°C; 2 h;
2: With ammonium chloride in tetrahydrofuran
参考文献
PFIZER LIMITED; BURGESS, Gary
Patent: WO2012/114223 A1, 2012 ;
Location in patent: Page/Page column 37 ;
WO 2012/114223 A1
反应条件
in tetrahydrofuran
T=10 - 20°C; 2 h;
参考文献
Xue, Chu-Biao; Metcalf, Brian W.; Han, Amy Qi; Robinson, Darius J.; Zheng, Changsheng; Wang, Anlai; Zhang, Yingxin
Patent: US2005/192302 A1, 2005 ;
Location in patent: Page/Page column 22 ;
US 20050192302 A1
反应条件
tert.-butyl lithium
1.) THF, -60 deg C, 3 h, 2.) THF, RT, overnight; Yield given. Multistep reaction;
参考文献
Cory; Walker; Zabel
Synthetic Communications, 1994 , vol. 24, # 6 p. 799 - 807
反应条件
in tetrahydrofuran
T=10 - 20°C; Grignard reaction; 3 h;
参考文献
Ekkati, Anil R.; Mandiyan, Valsan; Ravindranathan, Krishna P.; Bae, Jae H.; Schlessinger, Joseph; Jorgensen, William L.
Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2228 - 2231
反应条件
trifluoroacetic acid in dichloromethane
2 h; Ambient temperature;
参考文献
Cory; Walker; Zabel
Synthetic Communications, 1994 , vol. 24, # 6 p. 799 - 807
参考文献
Bock, Mark G.; Kuduk, Scott D.; Su, Dai-Shi; Wood, Michael R.
Patent: US2005/261327 A1, 2005 ;
Location in patent: Page/Page column 14; 23 ;
US 20050261327 A1
