4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE合成路线 (共 6 条)
反应条件
1: 4-chloro-7H-pyrrolo[2,3-d]-pyrimidine With sodium hydride in N,N-dimethyl acetamide T=-5°C; Inert atmosphere; 2: trimethylsilyl ethoxymethyl chloride in N,N-dimethyl acetamide T=0 - 5°C; Inert atmosphere;
参考文献
Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng
Patent: US2010/190981 A1, 2010 ;
Location in patent: Page/Page column 73 ;
US 20100190981 A1
反应条件
1: hydrogenchloride / water / 2.5 h / 20 °C 2: trichlorophosphate / 2.5 h / 100 °C / |Inert atmosphere 3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 22 p. 6770 - 6789
反应条件
1: trichlorophosphate / 2.5 h / 100 °C / |Inert atmosphere 2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 22 p. 6770 - 6789
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water T=90°C; 2 h; Inert atmosphere;
参考文献
Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng
Patent: US2010/190981 A1, 2010 ;
Location in patent: Page/Page column 75-76 ;
US 20100190981 A1
反应条件
water; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in butan-1-ol T=100°C; Inert atmosphere;
参考文献
Huang, Taisheng; Xue, Chu-Biao; Wang, Anlai; Kong, Ling Quan; Ye, Hai Fen; Yao, Wenqing; Rodgers, James D.; Shepard, Stacey; Wang, Haisheng; Shao, Lixin; Li, Hui-Yin; Li, Qun
Patent: US2011/224190 A1, 2011 ;
Location in patent: Page/Page column 37-38 ;
US 20110224190 A1
反应条件
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; butan-1-ol / 90 °C / |Inert atmosphere; |Large scale 2: hydrogenchloride / water; tetrahydrofuran / 16 - 30 °C / |Large scale View Scheme
参考文献
INCYTE CORPORATION; ZHOU, Jiacheng; LIU, Pingli; CAO, Ganfeng; WU, Yongzhong
Patent: WO2013/36611 A1, 2013 ;