3-环戊基-3-[4-[7-[[2-(三甲基硅烷基)乙氧基]甲基]-7H-吡咯并[2,3-d]嘧啶-4-基]-1H-吡唑-1-基]丙腈合成路线 (共 3 条)
反应条件
1: ethanol; hexane / |Resolution of racemate 2: trifluoroacetic acid / dichloromethane / 6 h 3: isopropyl alcohol / 20 °C / |Heating View Scheme
反应条件
1: ethanol; hexane / |Resolution of racemate 2: trifluoroacetic acid / dichloromethane / 6 h View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: ethanol; hexane / |Resolution of racemate 2: trifluoroacetic acid / dichloromethane / 6 h 3: phosphoric acid / isopropyl alcohol / 20 °C / |Heating View Scheme