3,5-二异丙氧基苯甲醛合成路线 （共 13 条）
反应条件
1: 70 percent / acetic anhydride; Et3N / 12 h / 110 °C 2: 84 percent / quinoline; copper chromite / 1 h / 230 - 240 °C 3: 90 percent / BCl3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 18 p. 3315 - 3321
反应条件
1: 72 percent / acetic anhydride; Et3N / 12 h / 110 °C 2: 96 percent / quinoline; copper chromite / 1 h / 230 - 240 °C 3: BCl3 / CH2Cl2 / 2.25 h / -78 - 0 °C View Scheme
参考文献
Solladie, Guy; Pasturel-Jacope, Yacine; Maignan, Jean
Tetrahedron, 2003 , vol. 59, # 18 p. 3315 - 3321
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C; 18 h;
参考文献
Christ, Andreas D.; Martin, Rainer E.; Mohr, Peter
Patent: US2008/64697 A1, 2008 ;
Location in patent: Page/Page column 29-30; 34 ;
US 20080064697 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=55°C; 2.5 h;
参考文献
Solladie, Guy; Pasturel-Jacope, Yacine; Maignan, Jean
Tetrahedron, 2003 , vol. 59, # 18 p. 3315 - 3321
反应条件
1: With diisobutylaluminium hydride in dichloromethane
T=-78°C; 0.5 h;
2: With manganese(IV) oxide in dichloromethane
72 h; Further stages.;
参考文献
Fei, Zhongbo; McDonald, Frank E.
Organic Letters, 2007 , vol. 9, # 18 p. 3547 - 3550
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 0.75 h; Overall yield = 97 percent;
参考文献
St. John, Sarah E.; Jensen, Katherine C.; Kang, Soosung; Chen, Yafang; Calamini, Barbara; Mesecar, Andrew D.; Lipton, Mark A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 19 p. 6022 - 6037
反应条件
potassium carbonate in water; acetone
参考文献
G.D. SEARLE and CO.
Patent: EP850221 B1, 2001 ;
反应条件
1.1: 60 percent / K2CO3 / dimethylformamide / 60 h / 80 °C
2.1: DIBAL-H / CH2Cl2 / 0.5 h / -78 °C
2.2: 83 percent / MnO2 / CH2Cl2 / 72 h
View Scheme
参考文献
Fei, Zhongbo; McDonald, Frank E.
Organic Letters, 2007 , vol. 9, # 18 p. 3547 - 3550
参考文献
Anthoni, Uffe; Encarnacion D., Rosalba; Nielsen, Per H.; Christophersen, Garsten
Acta Chemica Scandinavica, 1998 , vol. 52, # 10 p. 1243 - 1246
反应条件
1: 8.6 g / potassium carbonate, potassium iodide / dimethylformamide / 120 h / 50 °C
2: 7.34 g / lithium aluminium hydride / diethyl ether / 0.25 h / Heating
3: 13.6 g / manganese dioxide / benzene / 5 h / Heating
View Scheme
参考文献
Sargent, Melvyn V.; Stanojevic, Edi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 8 p. 1919 - 1921
