3-溴噻吩并[3,2-b]吡啶合成路线 （共 4 条）
反应条件
dipotassium hydrogenphosphate; bromine; sodium hydrogencarbonate; magnesium sulfate in chloroform Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/36541 A1, 2008 ;
Location in patent: Page/Page column 26 ;
WO 2008/036541 A1
反应条件
1: 69 percent / 625 °C 2: 57 percent / NaHCO3, MgSO4, K2HPO4, Br2 / CHCl3 / 72 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, p. 785 - 790
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol; water
T=130°C; 0.5 h; Microwave;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/36541 A1, 2008 ;
Location in patent: Page/Page column 26 ;
WO 2008/036541 A1
反应条件
copper(l) chloride in N,N-dimethyl-formamide
T=120°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/107784 A1, 2006 ;
Location in patent: Page/Page column 99-100 ;
WO 2006/107784 A1
