1: 96 percent / aq. KOH / ethanol 2: oxalyl chloride / benzene; dimethylformamide / 1 h / Ambient temperature 3: aq. Na2CO3 / tetrahydrofuran / 1 h / Ambient temperature 4: 83 percent / pyridine / ethanol / Heating 5: FeSO4, aq. conc. NH3 / 0.25 h / Heating 6: TsOH / toluene; tetrahydrofuran / 48 h / Heating View Scheme

1: 96 percent / aq. KOH / ethanol 2: oxalyl chloride / benzene; dimethylformamide / 1 h / Ambient temperature 3: aq. Na2CO3 / tetrahydrofuran / 1 h / Ambient temperature 4: NaBH3CN / ethanol / 3 h 5: H2 / 10percent Pd/C / ethanol / 4 h 6: 2.) conc. NH4OH / 1.) EtOH, RT, 16 h, 2.) EtOH, RT, 30 min View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: sulfuric acid; nitric acid / 0.5 h / -20 - -10 &deg;C / Inert atmosphere<br />1.2: 0.5 h / -10 - 5 &deg;C / Inert atmosphere<br />1.3: 48 h / Inert atmosphere<br />2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / Inert atmosphere<br /> <br /> &nbsp;