1,2,3,4-四氢咔唑合成路线 （共 202 条）
反应条件
hydrogen; Pt/Al2O3 in various solvent(s) T=250°C; P=116875 Torr; 3.2 h; Yield given. Yields of byproduct given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 1477 - 1483
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron, 1983 , vol. 39, # 22 p. 3767 - 3776
反应条件
1: With sodium methylate in methanol T=20°C; 2 h; 2: With sulfuric acid in methanol T=90°C; Fischer cyclization; 3 h; Further stages.;
参考文献
Simoneau, Christopher A.; Strohl, Alexis M.; Ganem, Bruce
Tetrahedron Letters, 2007 , vol. 48, # 10 p. 1809 - 1811
反应条件
1: 88 percent / Cu powder / Pd(dba)2 / dimethylsulfoxide / 1.5 h / 70 °C 2: 60 percent / H2 / 10 percent Pd/C / methanol / 0.75 h / 735.51 Torr View Scheme
参考文献
Organic Letters, , vol. 5, # 14 p. 2497 - 2500
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=100°C; Inert atmosphere;
参考文献
Jolly, Phillip I.; Fleary-Roberts, Nadia; O'Sullivan, Steven; Doni, Eswararao; Zhou, Shengze; Murphy, John A.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5807 - 5810
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tri-ruthenium(0)dodecacarbonyl; toluene-4-sulfonic acid in 1,4-dioxane T=150°C; 22 h; Inert atmosphere; Reagent/catalystSolventTemperatureTime;
参考文献
Pena-Lopez, Miguel; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2014 , vol. 20, # 7 p. 1818 - 1824
反应条件
tris-(2-chloro-ethyl)-amine; sulfuric acid in benzene
参考文献
Adam, G.; Andrieux, J.; Plat, M
Tetrahedron, 1985 , vol. 41, # 2 p. 399 - 408
反应条件
1: 87 percent / Cu powder / Pd(dba)2 / dimethylsulfoxide / 11 h / 70 °C 2: 60 percent / H2 / 10 percent Pd/C / methanol / 0.75 h / 735.51 Torr View Scheme
参考文献
Organic Letters, , vol. 5, # 14 p. 2497 - 2500
反应条件
1: 88 percent / Cu powder / Pd(dba)2 / dimethylsulfoxide / 1.5 h / 70 °C 2: 60 percent / H2 / 10 percent Pd/C / methanol / 0.75 h / 735.51 Torr View Scheme
参考文献
Organic Letters, , vol. 5, # 14 p. 2497 - 2500
反应条件
FeBr2 in toluene T=140°C; 16 h; Schlenk techniqueInert atmosphere;
参考文献
Nguyen, Quyen; Nguyen, Tuyen; Driver, Tom G.
Journal of the American Chemical Society, 2013 , vol. 135, # 2 p. 620 - 623
