1,2,3,4-四氢咔唑合成路线 （共 202 条）
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere 2: trifluoromethanesulfonyl azide; copper(II) sulfate; triethylamine / methanol; dichloromethane; water / 20 °C / Inert atmosphere 3: dirhodium(II) tetraoctanoate / 1,2-dichloro-ethane / 16 h / 70 °C / Inert atmosphere; Molecular sieve View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 7 p. 1702 - 1706
反应条件
1: trifluoromethanesulfonyl azide; copper(II) sulfate; triethylamine / methanol; dichloromethane; water / 20 °C / Inert atmosphere 2: dirhodium(II) tetraoctanoate / 1,2-dichloro-ethane / 16 h / 70 °C / Inert atmosphere; Molecular sieve View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 7 p. 1702 - 1706
反应条件
1: 2,6-di-tert-butyl-pyridine / 1,2-dichloro-ethane / 2 h / 70 °C / Inert atmosphere 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere 3: trifluoromethanesulfonyl azide; copper(II) sulfate; triethylamine / methanol; dichloromethane; water / 20 °C / Inert atmosphere 4: dirhodium(II) tetraoctanoate / 1,2-dichloro-ethane / 16 h / 70 °C / Inert atmosphere; Molecular sieve View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 7 p. 1702 - 1706
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere 2: trifluoromethanesulfonyl azide; copper(II) sulfate; triethylamine / methanol; dichloromethane; water / 20 °C / Inert atmosphere 3: dirhodium(II) tetraoctanoate / 1,2-dichloro-ethane / 16 h / 70 °C / Inert atmosphere; Molecular sieve View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 7 p. 1702 - 1706
反应条件
1: [Rh(bis(1-pyrazolyl)methane)(CO)2](tetrakis[3,5-bis(trifluoromethyl)phenyl]borate) / deuterated toluene / 0.04 h / 100 °C / |Inert atmosphere 2: C22H25ClIrN6O2(1+)*C32H12BF24(1-); potassium hydroxide / deuterated toluene / 100 h / 110 °C / |Inert atmosphere View Scheme
参考文献
Organometallics, , vol. 31, # 21 p. 7500 - 7510
反应条件
1: sodium hydride / N,N-dimethyl-formamide 2: diisobutylaluminium hydride / toluene / 20 °C / |Inert atmosphere 3: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / |Inert atmosphere 4: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / |Inert atmosphere 5: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling 6: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 2 p. 620 - 623
反应条件
1: diisobutylaluminium hydride / toluene / 20 °C / |Inert atmosphere 2: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / |Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / |Inert atmosphere 4: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling 5: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 2 p. 620 - 623
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / |Inert atmosphere 3: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling 4: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 2 p. 620 - 623
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / |Inert atmosphere 2: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling 3: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 2 p. 620 - 623
反应条件
hydrogenchloride; water T=150°C;
参考文献
Journal of the Chemical Society, , p. 4114
