4,5-二氯邻苯二甲酸酐合成路线 （共 38 条）
反应条件
1: KF / tetrahydrothiophene 1,1-dioxide / 2 h / 185 °C 2: 78 percent / NaOMe, NH2OH*HCl / methanol / 3 h / Ambient temperature 3: p-TsCl, 10percent aq. NaOH View Scheme
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
1: KF / tetrahydrothiophene 1,1-dioxide / 2 h / 185 °C 2: 2.) oxalyl chloride / 1.) 10 min, 2.) CH2Cl2, 16 h 3: 75 percent / tetrahydrofuran / 24 h 4: CCl3Br, AIBN / 6 h / Heating 5: aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Braish; Fox
Synthetic Communications, 1992 , vol. 22, # 21 p. 3067 - 3074
反应条件
sodium acetate T=240°C; 1 h;
参考文献
Zhang, Bo; Xu, Ming-Hua; Lin, Guo-Qiang
Organic Letters, 2009 , vol. 11, # 20 p. 4712 - 4715
反应条件
1: 89 g / LiAlH4 / tetrahydrofuran / 2.5 h / Heating 2: 77 g / 45percent HBr / H2O / 4 h / Heating 3: 18 g / Na2S*9H2O / 0.5 h 4: 13.4 g / 40percent CH3CO2OH / CHCl3 5: 5.9 g / 7 h / 230 °C 6: 5.4 g / NBS, AIBN / acetic anhydride / 1.5 h / Heating 7: 4.1 g / methanol / 2 h / Heating 8: 2.3 g / Et3N, diphenylphosphoryl azide / 6 h / Heating 9: 1.8 g / HCl / diethyl ether 10: 1.) NaNO2, HCl, 2.) CuCl, HCl / 1.) H2O, 0 deg C View Scheme
参考文献
Levy, Louis A.
Synthetic Communications, 1983 , vol. 13, # 8 p. 639 - 648
反应条件
1: 98 percent / formamide / 3 h / Heating 2: 72 percent / 25-33percent NH4OH / 48 h / Ambient temperature 3: 75 percent / SOCl2, DMF / 1) 0 - 5 deg C, 5 h, 2) r.t., 24 h View Scheme
参考文献
Liu, Junzhi; Yan, Yuzhi; Chen, Zhihua; Gu, Yi; Liu, Xikui
Chemistry Letters, 2010 , vol. 39, # 11 p. 1194 - 1196
反应条件
formamide T=180 - 190°C;
参考文献
Zhang, Lei; Chen, Xiaojie; Liu, Jun; Zhu, Qingzhang; Leng, Ying; Luo, Xiaomin; Jiang, Hualiang; Liu, Hong
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 624 - 639
反应条件
1: 98 percent / formamide / 3 h / Heating 2: 72 percent / 25-33percent NH4OH / 48 h / Ambient temperature View Scheme
参考文献
Liu, Junzhi; Yan, Yuzhi; Chen, Zhihua; Gu, Yi; Liu, Xikui
Chemistry Letters, 2010 , vol. 39, # 11 p. 1194 - 1196
反应条件
1: 98 percent / formamide / 3 h / Heating 2: 72 percent / 25-33percent NH4OH / 48 h / Ambient temperature 3: 75 percent / SOCl2, DMF / 1) 0 - 5 deg C, 5 h, 2) r.t., 24 h 4: 51 percent / K2CO3 / dimethylsulfoxide / 0.5 h / 90 °C View Scheme
参考文献
Wohrle; Eskes; Shigehara; Yamada
Synthesis, 1993 , # 2 p. 194 - 196
反应条件
potassium acetate 5 h; Heating;
参考文献
Kreher, Richard P.; Hennige, Hans; Konrad, Michael; Uhrig, Juergen; Clemens, Andrea
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1991 , vol. 46, # 6 p. 809 - 828
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2.5 h; Heating;
参考文献
Levy, Louis A.
Synthetic Communications, 1983 , vol. 13, # 8 p. 639 - 648
