2-巯基-S-硫代苯甲酰乙酸合成路线 （共 56 条）
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/73147 A2, 2009 ;
Location in patent: Page/Page column 37 ;
反应条件
sodium hydroxide in water
T=0 - 10°C; 0.5 h;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/73147 A2, 2009 ;
Location in patent: Page/Page column 34-35 ;
参考文献
Jensen,K.A. et al.
Acta Chemica Scandinavica (1947-1973), 1961 , vol. 15, p. 1109 - 1123
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Holmberg
Arkiv foer Kemi, 1952 , vol. 4, p. 33,81
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Jensen; Miquel
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 189,191
反应条件
1: 68.3 percent / hydrazine hydrate (50 percent), aq.potassium hydroxide (1 N) / -6 - 0 °C
2: 86.8 percent / ethanol / 4 h / Heating
View Scheme
参考文献
Tomchin, A.B.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 504 - 510
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 3 p. 589 - 595
反应条件
sodium hydrogencarbonate in water
pH 8;
参考文献
Zelenin, K. N.; Khrustalev, V. A.; Alekseev, V. V.; Sharbatyan, P. A.; Lebedev, A. T.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 7 p. 683 - 689
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , # 7 p. 904 - 910
反应条件
potassium hydroxide in acetonitrile
Heating;
参考文献
Uhlemann, Erhard; Huebner, Wolfgang; Ludwig, Eberhard
Zeitschrift fuer Chemie (Stuttgart, Germany), 1981 , vol. 21, # 11 p. 413 - 414
反应条件
1: aq. NaOH, N2H4
2: aq. ethanol
View Scheme
参考文献
Jensen,K.A.; Pedersen,C.
Acta Chemica Scandinavica (1947-1973), 1961 , vol. 15, p. 1097 - 1103
参考文献
Leon,N.H.; Asquith,R.S.
Tetrahedron, 1970 , vol. 26, p. 1719 - 1725
参考文献
Prangova, Lilia; Boege, Askan; Wollny, Bernd; Voss, Juergen
Journal of Chemical Research, Miniprint, 1987 , # 6 p. 1601 - 1616
反应条件
sodium hydroxide
1 h; Ambient temperature;
参考文献
Coates, Robert M.; Firsan, Sharbil J.
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5198 - 5209
