(9CI)-噻吩并[3,2-c]吡啶-2-羧醛合成路线 (共 3 条)
反应条件
1: thieno(3,2-c)-pyridine With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.0833333 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=20°C; 16 h;
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2004/52890 A1, 2004 ;
Location in patent: Page 90-91 ;
WO 2004/052890 A1
反应条件
1: thieno(3,2-c)-pyridine With lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
2: formic acid ethyl ester in tetrahydrofuran
参考文献
Lu, Zhijian; Bohn, Joann; Rano, Tom; Rutkowski, Carrie A.; Simcoe, Amy L.; Olsen, David B.; Schleif, William A.; Carella, Anthony; Gabryelski, Lori; Jin, Lixia; Lin, Jiunn H.; Emini, Emilio; Chapman, Kevin; Tata, James R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 23 p. 5311 - 5314
反应条件
hydrogenchloride; sodium hydroxide; n-butyllithium; diisopropylamine in tetrahydrofuran; hexane; water; acetic acid; N,N-dimethyl-formamide
参考文献
Eli Lilly and Company
Patent: US4480098 A1, 1984 ;