1-(3-羟基苯基)-2-(甲氨基)乙酮盐酸盐合成路线 （共 8 条）
反应条件
1: in tetrahydrofuran T=5°C; 2.5 h; ice-salt bath; 2: With hydrogenchloride in tetrahydrofuran; water T=0°C; 0.5 h;
参考文献
LONZA AG
Patent: WO2008/95678 A1, 2008 ;
Location in patent: Page/Page column 11-12 ;
反应条件
hydrogen; palladium in ethanol
参考文献
Pharmaceutical Chemistry Journal, , vol. 22, # 11 p. 857 - 863
Khimiko-Farmatsevticheskii Zhurnal, , vol. 22, # 11 p. 1349 - 1355
反应条件
potassium hydroxide; hydrogen; [(R)-P-Phos RuCl2 (R)-DAIPEN] in water; isopropyl alcohol T=65°C; P=21002.1 Torr; 1 h; Product distribution / selectivity;
参考文献
LONZA AG
Patent: WO2008/77560 A1, 2008 ;
Location in patent: Page/Page column 10-11 ;
反应条件
C65H76Cl2N4O6P2Ru; hydrogen; potassium hydroxide in water; isopropyl alcohol T=65°C; P=21752.2 - 24752.5 Torr; 2.25 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
McGarrity, John F.; Zanotti-Gerosa, Antonio
Tetrahedron Asymmetry, 2010 , vol. 21, # 20 p. 2479 - 2486
反应条件
hydrogen; [Rh(cod)(R-Binapine)]BF4 in methanol T=65°C; P=21752.2 - 24752.5 Torr; 18.25 h; Product distribution / selectivity;
参考文献
LONZA AG
Patent: WO2008/95678 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrogen; [(S)-Xyl-P-Phos RuCl(p-cymene)]Cl in methanol T=80 - 85°C; P=18751.9 - 23252.3 Torr; 21 h; Product distribution / selectivity;
参考文献
LONZA AG
Patent: WO2008/77560 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With potassium hydroxide; hydrogen; [(S)-Xyl-P-Phos RuCl2 (S)-DAIPEN] in water; isopropyl alcohol
T=70°C; P=21752.2 - 24752.5 Torr; 2.75 h;
2: With hydrogenchloride in ethanol; water; isopropyl alcohol
T=20°C; Product distribution / selectivity;
参考文献
LONZA AG
Patent: WO2008/77560 A1, 2008 ;
Location in patent: Page/Page column 11-12 ;
反应条件
hydrogen; [(S)-Xyl-P-Phos RuCl(p-cymene)]Cl in methanol
T=80 - 85°C; P=18751.9 - 23252.3 Torr; 21 h; Product distribution / selectivity;
参考文献
LONZA AG
Patent: WO2008/77560 A1, 2008 ;
Location in patent: Page/Page column 12 ;
