1-环丙基-6,7,8-三氟-1,4-二氢-4-氧代-3-喹啉羧酸乙酯合成路线 （共 17 条）
反应条件
1: 1.) Ac2O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght
2: t-BuOK / 2-methyl-propan-2-ol / 18 h / 50 °C
View Scheme
参考文献
Domagala, John M.; Heifetz, Carl L.; Hutt, Marland P.; Mich, Thomas F.; Nichols, Jeffry B.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 991 - 1001
反应条件
1: tetrahydrofuran / 0.75 h / -78 °C
2: 1.) Ac2O / 1.) 150 deg C, 2 h, 2.) t-BuOH, 10 deg C, 30 min; 45 deg C, overnoght
3: t-BuOK / 2-methyl-propan-2-ol / 18 h / 50 °C
View Scheme
参考文献
Domagala, John M.; Heifetz, Carl L.; Hutt, Marland P.; Mich, Thomas F.; Nichols, Jeffry B.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 991 - 1001
反应条件
1: 95 percent / ethanol / 1 h / Ambient temperature
2: 78 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: p-toluenesulfonic acid / H2O / 5 h / Heating
2: acetic anhydride / 2 h / Heating
3: 95 percent / ethanol / 1 h / Ambient temperature
4: 78 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
Yield given. Multistep reaction;
参考文献
Clay; Collom; Karrick; Wemple
Synthesis, 1993 , # 3 p. 290 - 292
反应条件
trimethylsilyl iodide in dichloromethane; acetonitrile
参考文献
Warner-Lambert Company
Patent: US4578473 A1, 1986 ;
反应条件
1: HCl / acetic acid / 2 h / 100 °C
2: 87 percent / DBU / acetonitrile / 1.) reflux, 2.5 h, 2.) room temperature, overnight
View Scheme
参考文献
Domagala, John M.; Heifetz, Carl L.; Hutt, Marland P.; Mich, Thomas F.; Nichols, Jeffry B.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 991 - 1001
