2-甲基-2-丙基4-硝基-11-氮杂三环[6.2.1.02,7]十一碳-2,4,6-三烯-11-羧酸酯合成路线 （共 5 条）
反应条件
1: (+/-)-2,2,2-trifluoro-1-(6-nitro-1,2,3,4-tetrahydro-1,4-epiazano-naphthalen-9-yl)-ethanone With lithium hydroxide; water in tetrahydrofuran
T=25°C; 1 h;
2: di-tert-butyl dicarbonate in tetrahydrofuran; water
T=25°C; 2 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/72158 A2, 2007 ;
Location in patent: Page/Page column 90 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol
T=20°C; 7 h;
参考文献
Ohwada, Tomohiko; Ishikawa, Satoko; Mine, Yusuke; Inami, Keiko; Yanagimoto, Takahiro; Karaki, Fumika; Kabasawa, Yoji; Otani, Yuko; Mochizuki, Masataka
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2726 - 2741
反应条件
1.1: hydrogenchloride; isopentyl nitrite / ethanol; water / 1.25 h / 0 °C
1.2: 20 °C / Reflux
2.1: palladium 10 on activated carbon; hydrogen / methanol / 7 h / 20 °C
View Scheme
参考文献
Ohwada, Tomohiko; Ishikawa, Satoko; Mine, Yusuke; Inami, Keiko; Yanagimoto, Takahiro; Karaki, Fumika; Kabasawa, Yoji; Otani, Yuko; Mochizuki, Masataka
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2726 - 2741
反应条件
1.1: hydrogenchloride; isopentyl nitrite / ethanol; water / 1.25 h / 0 °C
1.2: 20 °C / Reflux
2.1: palladium 10 on activated carbon; hydrogen / methanol / 7 h / 20 °C
View Scheme
参考文献
Ohwada, Tomohiko; Ishikawa, Satoko; Mine, Yusuke; Inami, Keiko; Yanagimoto, Takahiro; Karaki, Fumika; Kabasawa, Yoji; Otani, Yuko; Mochizuki, Masataka
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2726 - 2741
反应条件
in n-heptane; isopropyl alcohol
Resolution of racemate;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/72158 A2, 2007 ;
Location in patent: Page/Page column 90-91 ;
