反应条件
1.1: trans-2-aminocyclohexanol hydrochloride; NiI2; sodium hexamethyldisilazane / isopropyl alcohol / 0.17 h / 20 °C / |Inert atmosphere
1.2: 1 h / 80 °C
2.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C
View Scheme
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
