1: With water; potassium hydroxide in 2-methyl tetrahydrofuran T=40°C; 2: With hydrogenchloride in 2-methyl tetrahydrofuran; water T=20°C; pH=< 7; Cooling; Product distribution / selectivity;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2009/123714 A2, 2009 ;
Location in patent: Page/Page column 54-55 ;
WO 2009/123714 A2