反应条件
1: 1.) COCl2, 2.) triethylamine / 1.) RT, 18 h, 2.) petroleum ether, CH2Cl2, 0 deg C, 30 min 2: 53 percent / 60 percent NaH, 1.46 M n-BuLi / tetrahydrofuran; hexane / 20 min, rt; 0 deg C, 10 min; 0 deg C, 1-2 h 3: 1.) TFA, 2.) acetic anhydride / 1.) CH2Cl2, rt, 1 h, 2.) rt, 18 h 4: K2CO3 / dimethylformamide / 18 h / Ambient temperature View Scheme
参考文献
Lygo, Barry
Tetrahedron, 1995 , vol. 51, # 47 p. 12859 - 12868
