5-(2-氯乙基)-2,3-二氢苯并呋喃合成路线 （共 5 条）
反应条件
thionyl chloride in toluene T=25 - 60°C; 14 h;
参考文献
TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/76157 A2, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
triethylsilane; trifluoroacetic acid T=0 - 35°C; 10 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/100651 A2, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
1: UK-88862 With sodium hydroxide; water in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride With triethylamine T=95°C; 15 h; 3: With hydrogen bromide in water; acetone 1 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/100651 A2, 2008 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1: With potassium carbonate in water T=101 - 103°C; 2.5 - 5 h; 2: With hydrogen bromide in water; butan-1-ol Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/76157 A2, 2007 ;
Location in patent: Page/Page column 45; 46; 49 ;
反应条件
sodium bromide in acetone 48 h; Heating / reflux;
参考文献
SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi
Patent: WO2008/126106 A2, 2008 ;
Location in patent: Page/Page column 18; 34 ;
