3-氨基-3-(噻吩-3-基)丙酸合成路线 （共 8 条）
反应条件
ammonium acetate in ethanol 7 h; Reflux;
参考文献
Prado-Prado, Francisco; Garcia-Mera, Xerardo; Abeijon, Paula; Alonso, Nerea; Caamano, Olga; Yanez, Matilde; Garate, Teresa; Mezo, Mercedes; Gonzalez-Warleta, Marta; Muino, Laura; Ubeira, Florencio M.; Gonzalez-Diaz, Humberto
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1074 - 1094
反应条件
ammonium acetate; malonic acid in isopropyl alcohol
反应条件
malonic acid in ethanol Rodionow-Johnson;
参考文献
Pharmacy and Pharmacology Communications, , vol. 5, # 3 p. 217 - 223
反应条件
ammonium acetate; ethanol; malonic acid
参考文献
Zhurnal Obshchei Khimii, , vol. 27, p. 464; engl. Ausg. S. 525
反应条件
1: TFA-anhydride / 1 h at room temperature then 3 h reflux View Scheme
参考文献
Dallemagne, P.; Rault, S.; Sevricourt, Cugnon de M.; Hassan, Kh. M.; Robba, M.
Tetrahedron Letters, 1986 , vol. 27, # 23 p. 2607 - 2610
反应条件
1: 66 percent / TFA / 1.) RT, 20 min, 2.) reflux, 3 h 2: 90 percent / 6 N aq. HCl / 0.5 h / Heating View Scheme
参考文献
Quermonne; Dallemagne; Louchahi-Raoul; Pilo; Rault; Robba
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 9 p. 961 - 965
反应条件
1: 3-amino-3-(thien-3-yl)propanoic acid With trifluoroacetic acid T=20°C; 0.5 h; Inert atmosphere; 2: trifluoroacetic anhydride 5 h; Reflux;
参考文献
Prado-Prado, Francisco; Garcia-Mera, Xerardo; Abeijon, Paula; Alonso, Nerea; Caamano, Olga; Yanez, Matilde; Garate, Teresa; Mezo, Mercedes; Gonzalez-Warleta, Marta; Muino, Laura; Ubeira, Florencio M.; Gonzalez-Diaz, Humberto
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1074 - 1094
反应条件
trifluoroacetic anhydride 1 h at room temperature then 3 h reflux; Yield given;
参考文献
Dallemagne, P.; Rault, S.; Sevricourt, Cugnon de M.; Hassan, Kh. M.; Robba, M.
Tetrahedron Letters, 1986 , vol. 27, # 23 p. 2607 - 2610
