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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
943439-56-3
合成路线
（共 4 条）
943439-56-3
→
反应条件
182133-25-1
阿佐昔芬
反应条件
1.1: HCl / CH2Cl2; diethyl ether / 0.5 h / 20 °C 1.2: 82 percent / BF3*SMe2 / CH2Cl2 / 5 h / 20 °C 2.1: 85 percent / CuI; ethyl acetate / dimethylformamide; methanol / 8 h / 110 °C View Scheme
参考文献
Qin, Zhihui; Kastrati, Irida; Chandrasena, R. Esala P.; Liu, Hong; Yao, Ping; Petukhov, Pavel A.; Bolton, Judy L.; Thatcher, Gregory R. J.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2682 - 2692
943439-52-9
→
反应条件
943439-56-3
反应条件
<b>Multi-step reaction with 4 steps<br /> </b>1.1: 95 percent / N-bromoacetamide / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / 20 °C<br />2.1: 65 percent / TFA; aq. H<sub>2</sub>O<sub>2</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / 20 °C<br />3.1: NaH / dimethylformamide / 0.33 h<br />3.2: 94 percent / dimethylformamide / 1 h / 20 °C<br />4.1: HCl / CH<sub>2</sub>Cl<sub>2</sub>; diethyl ether / 1 h<br />4.2: 85 percent / TMSCl; Ph<sub>3</sub>P / tetrahydrofuran / 8 h / Heating<br /> <br />
参考文献
Qin, Zhihui; Kastrati, Irida; Chandrasena, R. Esala P.; Liu, Hong; Yao, Ping; Petukhov, Pavel A.; Bolton, Judy L.; Thatcher, Gregory R. J. Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2682 - 2692
15570-12-4
3-甲氧基苯硫酚
→
反应条件
943439-56-3
反应条件
<b>Multi-step reaction with 6 steps<br /> </b>1.1: KOH / ethanol<br />1.2: 89 percent / ethanol; ethyl acetate / 20 °C<br />2.1: 30 percent / PPA / 6 h / Heating<br />3.1: 95 percent / N-bromoacetamide / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / 20 °C<br />4.1: 65 percent / TFA; aq. H<sub>2</sub>O<sub>2</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / 20 °C<br />5.1: NaH / dimethylformamide / 0.33 h<br />5.2: 94 percent / dimethylformamide / 1 h / 20 °C<br />6.1: HCl / CH<sub>2</sub>Cl<sub>2</sub>; diethyl ether / 1 h<br />6.2: 85 percent / TMSCl; Ph<sub>3</sub>P / tetrahydrofuran / 8 h / Heating<br /> <br />
参考文献
Qin, Zhihui; Kastrati, Irida; Chandrasena, R. Esala P.; Liu, Hong; Yao, Ping; Petukhov, Pavel A.; Bolton, Judy L.; Thatcher, Gregory R. J. Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2682 - 2692
225222-73-1
2-(3-甲氧基苯基硫代)-1-(4-溴苯基)乙酮
→
反应条件
943439-56-3
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1.1: 30 percent / PPA / 6 h / Heating<br />2.1: 95 percent / N-bromoacetamide / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / 20 °C<br />3.1: 65 percent / TFA; aq. H<sub>2</sub>O<sub>2</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 2 h / 20 °C<br />4.1: NaH / dimethylformamide / 0.33 h<br />4.2: 94 percent / dimethylformamide / 1 h / 20 °C<br />5.1: HCl / CH<sub>2</sub>Cl<sub>2</sub>; diethyl ether / 1 h<br />5.2: 85 percent / TMSCl; Ph<sub>3</sub>P / tetrahydrofuran / 8 h / Heating<br /> <br />
参考文献
Qin, Zhihui; Kastrati, Irida; Chandrasena, R. Esala P.; Liu, Hong; Yao, Ping; Petukhov, Pavel A.; Bolton, Judy L.; Thatcher, Gregory R. J. Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2682 - 2692
