6,6-二甲基-3-氮杂双环[3.1.0]己烷合成路线 （共 4 条）
反应条件
hydrogen; palladium(II) oxide hydrate in methanol
T=20°C; P=3677.86 - 5149.01 Torr; Autoclave;
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
Location in patent: Page/Page column 38-39 ;
WO 2012/049688 A1
反应条件
sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran
T=-30 - 50°C; Product distribution / selectivity;
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
Location in patent: Page/Page column 36 ;
WO 2012/049688 A1
反应条件
1: urea / 160 - 170 °C / Neat (no solvent)
2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / -30 - 50 °C
View Scheme
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
WO 2012/049688 A1
反应条件
hydrogenchloride in toluene
T=5 - 10°C; 0.5 h; Product distribution / selectivity;
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
Location in patent: Page/Page column 36-37 ;
WO 2012/049688 A1
