6,6-二甲基-3-氮杂双环[3.1.0]己烷盐酸盐合成路线 （共 4 条）
反应条件
1: With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane
T=0 - 55°C; 6 h;
2: With methanol
T=65°C; 3 h;
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
Location in patent: Page/Page column 38-39 ;
WO 2012/049688 A1
反应条件
hydrogenchloride in toluene
T=5 - 10°C; 0.5 h; Product distribution / selectivity;
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
Location in patent: Page/Page column 36-37 ;
WO 2012/049688 A1
反应条件
1: urea / 160 - 170 °C / Neat (no solvent)
2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / -30 - 50 °C
3: hydrogenchloride / toluene / 0.5 h / 5 - 10 °C
View Scheme
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
WO 2012/049688 A1
反应条件
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / -30 - 50 °C
2: hydrogenchloride / toluene / 0.5 h / 5 - 10 °C
View Scheme
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
WO 2012/049688 A1
