2,2-二氟-2-(喹啉-6-基)乙酸肼合成路线 （共 3 条）
反应条件
hydrazine in ethanol
T=20°C; 0.166667 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; LI, Pan; WAAL, Nathan; RONKIN, Steven; TANG, Qing; LAUFFER, David
Patent: WO2010/138663 A1, 2010 ;
Location in patent: Page/Page column 26 ;
WO 2010/138663 A1
反应条件
hydrazine in methanol
2 h; Heating / reflux; Product distribution / selectivity;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/75567 A1, 2007 ;
Location in patent: Page/Page column 115 ;
WO 2007/075567 A1
反应条件
1: copper / dimethyl sulfoxide / 15 h / 55 °C / Inert atmosphere
2: hydrazine hydrate / methanol / 0.5 h / 45 °C
View Scheme
参考文献
NOVARTIS AG; FU, Xingnian; HE, Feng; LI, Yue; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YU, Zhengtian; ZHANG, Ji Yue (Jeff); DAI, Miao
Patent: WO2011/18454 A1, 2011 ;
WO 2011/018454 A1
