6-溴-7-甲基喹唑啉-4(3H)-酮合成路线 （共 5 条）
反应条件
1: With methanol; acetic acid T=20°C; 0.0833333 h; 2: With bromine T=20°C; 3 h;
参考文献
AMGEN INC.
Patent: WO2008/153947 A2, 2008 ;
Location in patent: Page/Page column 43; 58 ;
WO 2008/153947 A2
反应条件
1: 5-bromo-4-methylanthranilic acid With ammonia 1 h; Heating / reflux; 2: formamide 4 h; Heating / reflux; 3: With water 0.5 h; Heating / reflux;
参考文献
Gruenenthal GmbH
Patent: US2009/69320 A1, 2009 ;
Location in patent: Page/Page column 76 ;
反应条件
1: 6 h / 100 °C 2: acetic acid; bromine / methanol / 5 h / 20 °C View Scheme
反应条件
1: potassium hydroxide / ethanol / 8 h / |Reflux 2: 6 h / 100 °C 3: acetic acid; bromine / methanol / 5 h / 20 °C View Scheme
反应条件
sulfuric acid; potassium nitrate
T=80°C; 0.333333 h;
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 51 ;
