6-溴-7-甲基-8-硝基-4(3H)-喹唑啉酮合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 96 h;
参考文献
AMGEN INC.
Patent: WO2008/153947 A2, 2008 ;
Location in patent: Page/Page column 81-82 ;
WO 2008/153947 A2
反应条件
sulfuric acid; potassium nitrate
T=80°C; 0.333333 h;
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 51 ;
反应条件
1: 6 h / 100 °C
2: acetic acid; bromine / methanol / 5 h / 20 °C
3: sulfuric acid; potassium nitrate / 0.33 h / 80 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
反应条件
1: acetic acid; bromine / methanol / 5 h / 20 °C
2: sulfuric acid; potassium nitrate / 0.33 h / 80 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
反应条件
1: potassium hydroxide / ethanol / 8 h / |Reflux
2: 6 h / 100 °C
3: acetic acid; bromine / methanol / 5 h / 20 °C
4: sulfuric acid; potassium nitrate / 0.33 h / 80 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
