1-[3-(1-甲基乙基)苯基]-环丙胺合成路线 (共 1 条)
反应条件
1: With titanium(IV) isopropylate in diethylamine
T=-70°C; 1 h;
2: With boron trifluoride diethyl etherate in diethylamine
T=10°C; 1 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/77004 A1, 2007 ;
Location in patent: Page/Page column 102 ;