1-(7-溴-1H-吲哚-3-基)乙酮合成路线 （共 2 条）
反应条件
1: 7-Bromo-1H-indole With diethylaluminium chloride in dichloromethane
T=0°C; 0.416667 h;
2: acetyl chloride in dichloromethane
T=0°C; 1 - 3 h;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2007/79239 A2, 2007 ;
Location in patent: Page/Page column 75-76 ;
WO 2007/079239 A2
反应条件
1: 7-Bromo-1H-indole With tin(IV) chloride in dichloromethane
T=20°C; 0.5 h;
2: acetic anhydride in nitromethane; dichloromethane
T=20°C; 3 h; Further stages.;
参考文献
Simon, Gaelle; Couthon-Gourves, Helene; Haelters, Jean-Pierre; Corbel, Bernard; Kervarec, Nelly; Michaud, Francois; Meijer, Laurent
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 4 p. 793 - 801
