4-氯-2-氟-3-甲氧基苯硼酸合成路线 （共 4 条）
反应条件
1: With n-butyllithium in ethylene glycol dimethyl ether
T=-78 - -70.1°C; 1.75 h;
2: With boric acid trimethyl ester in ethylene glycol dimethyl ether
T=-67 - 20°C; TimeTemperature; Further stages;
参考文献
DOW AGROSCIENCES LLC; OPPENHEIMER, Jossian
Patent: WO2013/16557 A2, 2013 ;
Location in patent: Page/Page column 12 ;
反应条件
1: With water; potassium hydroxide
T=16 - 20°C; 0.25 h;
2: With hydrogenchloride in water
0.25 h;
参考文献
DOW AGROSCIENCES LLC; Emonds, Mark V. M.; Menning, Catherine A.; Blaylock, D. Wayne
Patent: US2013/66115 A1, 2013 ;
Location in patent: Paragraph 0045 ;
反应条件
1: 2,6-CFA With n-butyllithium in ethylene glycol dimethyl ether
T=-65°C; Inert atmosphere;
2: boric acid trimethyl ester in ethylene glycol dimethyl ether
T=-65 - 30°C; Inert atmosphere; Time;
参考文献
DOW AGROSCIENCES LLC; OPPENHEIMER, Jossian; EMONDS, Mark V.M.; DERSTINE, Christopher W.; CLOUSE, Robert C.
Patent: WO2013/102078 A1, 2013 ;
Location in patent: Page/Page column 15 ;
反应条件
1: in ethylene glycol dimethyl ether; hexane
T=-70 - -45°C; 0.25 h; Cooling with dry ice bath;
2: With hydrogenchloride; water in ethylene glycol dimethyl ether; hexane
Product distribution / selectivity;
参考文献
Dow AgroSciences LLC
Patent: US2009/182168 A1, 2009 ;
Location in patent: Page/Page column 2 ;
