hydrogen; palladium dihydroxide in methanol; water P=760 Torr; 22 h; Ambient temperature;

sodium hydroxide in 1,4-dioxane 6 h; Ambient temperature;

1: 81 percent / DMSO, dicyclohexylcarbodiimide, methylphosphonic acid / 20 h / Ambient temperature 2: 40 percent / H2 / Pd(OH)2/C / H2O; methanol / 22 h / 760 Torr / Ambient temperature View Scheme

1: 64 percent / 0.1 M HCl / 15 h / Heating 2: 45 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / dimethylformamide / 30 h / Heating 3: 74 percent / aq. M NaOH / dioxane / 6 h / Ambient temperature View Scheme

1: 45 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / dimethylformamide / 30 h / Heating 2: 74 percent / aq. M NaOH / dioxane / 6 h / Ambient temperature View Scheme

1: 38 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature 2: 64 percent / 0.1 M HCl / 15 h / Heating 3: 45 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / dimethylformamide / 30 h / Heating 4: 74 percent / aq. M NaOH / dioxane / 6 h / Ambient temperature View Scheme

1: 47 percent / CH2Cl2 / 72 h / Ambient temperature 2: 64 percent / 0.1 M HCl / 15 h / Heating 3: 45 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / dimethylformamide / 30 h / Heating 4: 74 percent / aq. M NaOH / dioxane / 6 h / Ambient temperature View Scheme