2,4,6-三甲基苯基丙二酸二乙酯合成路线 （共 9 条）
反应条件
1: diethyl malonate With sodium hydride in 1-methyl-pyrrolidin-2-one
T=0 - 20°C; Inert atmosphere;
2: 2,4,6-trimethylphenyl iodide With copper(l) iodide in 1-methyl-pyrrolidin-2-one
T=80 - 85°C; 5 h; Inert atmosphere;
参考文献
Muehlebach, Michel; Boeger, Manfred; Cederbaum, Fredrik; Cornes, Derek; Friedmann, Adrian A.; Glock, Jutta; Niderman, Thierry; Stoller, Andre; Wagner, Trixie
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 12 p. 4241 - 4256
反应条件
1: 1-fluoro-2,4,6-trimethylbenzene With (.eta.5-ethyltetramethylcyclopentadienyl)(.eta.6-benzene)rhodium(III) tetrafluoroborate in nitromethane
T=100°C; 2 h;
2: diethyl malonate With sodium hydride in tetrahydrofuran
48 h;
参考文献
Goryunov; Romanova; Zhilovskii; Shteingarts
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 12 p. 1765 - 1772
反应条件
1: 2,4,6-trimethylchlorobenzene With (.eta.5-ethyltetramethylcyclopentadienyl)(.eta.6-benzene)rhodium(III) tetrafluoroborate in nitromethane
T=100°C; 2 - 3 h;
2: diethyl malonate With lithium hydride in hexadeuterioacetone
48 h;
参考文献
Goryunov; Romanova; Zhilovskii; Shteingarts
Russian Journal of Organic Chemistry, 2007 , vol. 43, # 12 p. 1765 - 1772
反应条件
1: sulfuric acid
2: toluene; ethanolic sodium ethylate
View Scheme
参考文献
Fuson et al.
Journal of Organic Chemistry, 1944 , vol. 9, p. 187,190
反应条件
sodium ethanolate; toluene
参考文献
Fuson et al.
Journal of Organic Chemistry, 1944 , vol. 9, p. 187,190
反应条件
1: aq. ethanol
2: (saponification)
3: H2SO4 / Heating
4: (i) NaOEt, (ii) (decarboxylation)
View Scheme
参考文献
van Zanten,B.; Nauta,W.
Recueil des Travaux Chimiques des Pays-Bas, 1960 , vol. 79, p. 1211 - 1222
反应条件
1: aq. HCl
2: aq. ethanol
3: (saponification)
4: H2SO4 / Heating
5: (i) NaOEt, (ii) (decarboxylation)
View Scheme
参考文献
van Zanten,B.; Nauta,W.
Recueil des Travaux Chimiques des Pays-Bas, 1960 , vol. 79, p. 1211 - 1222
反应条件
1: toluene-sulfonic acid-(4)
2: toluene; ethanolic sodium ethylate
View Scheme
参考文献
Fuson et al.
Journal of Organic Chemistry, 1944 , vol. 9, p. 187,190
反应条件
2: toluene; ethanolic sodium ethylate
View Scheme
参考文献
Fuson et al.
Journal of Organic Chemistry, 1944 , vol. 9, p. 187,190
