5-溴-6-氟吡啶-2-胺合成路线 （共 3 条）
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / ethanol / 0.25 h / 140 °C / Microwave irradiation 2: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C 3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 4: boron tribromide / dichloromethane / 0 - 20 °C View Scheme
参考文献
Swahn, Britt-Marie; Sandell, Johan; Pyring, David; Bergh, Margareta; Jeppsson, Fredrik; Jureus, Anders; Neelissen, Jan; Johnstroem, Peter; Schou, Magnus; Svensson, Samuel
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 13 p. 4332 - 4337
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=115°C; 4.25 h; Heating / reflux;
参考文献
DANA-FARBER CANCER INSTITUTE, INC.; ZHAO, Jean J.; WANG, Qi
Patent: WO2012/109423 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
N-bromosuccinmide in acetonitrile
T=20°C; 1 h; Inert atmosphere;
参考文献
Sandell, Johan
Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 6 p. 321 - 324
