反应条件
1: sodium hydroxide; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; palladium diacetate / 1,4-dioxane; water / 2 h / 100 °C / |Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 20 °C
3: N-bromosuccinmide / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
UCB PHARMA S.A.; BENTLEY, Jonathan Mark; BROOKINGS, Daniel Christopher; BROWN, Julien Alistair; CAIN, Thomas Paul; CHOVATIA, Praful Tulshi; FOLEY, Anne Marie; GALLIMORE, Ellen Olivia; GLEAVE, Laura Jane; HEIFETZ, Alexander; HORSLEY, Helen Tracey; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; JOHNSON, James Andrew; JOHNSTONE, Craig; KROEPLIEN, Boris; LECOMTE, Fabien Claude; LEIGH, Deborah; LOWE, Martin Alexander; MADDEN, James; PORTER, John Robert; QUINCEY, Joanna Rachel; REED, Laura Claire; REUBERSON, James Thomas; RICHARDSON, Anthony John; RICHARDSON, Sarah Emily; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning
Patent: WO2014/9295 A1, 2014 ;