1-(5-溴-吡啶-2-基)-环丙胺合成路线 （共 3 条）
反应条件
1: With titanium(IV) isopropylate in diethyl ether
T=-78 - 20°C; 1.58333 h;
2: With boron trifluoride diethyl etherate in diethyl ether
2 h;
参考文献
SCHERING CORPORATION
Patent: WO2007/84451 A1, 2007 ;
Location in patent: Page/Page column 148 ;
WO 2007/084451 A1
反应条件
1.1: thionyl chloride / 3 h / Reflux
1.2: 20 °C / Cooling with ice
2.1: trichlorophosphate / toluene / 2 h / Reflux
2.2: pH 12 / Cooling with ice
3.1: titanium (IV) isopropoxide / diethyl ether / 0.08 h / -78 °C
3.2: 1.5 h / -78 - 20 °C
3.3: 2 h / 20 °C
View Scheme
参考文献
ROTTAPHARM S.P.A.; BORRIELLO, Manuela; ROVATI, Lucio; STASI, Luigi Piero; BUZZI, Benedetta; COLACE, Fabrizio
Patent: WO2012/76063 A1, 2012 ;
WO 2012/076063 A1
反应条件
1.1: trichlorophosphate / toluene / 2 h / Reflux
1.2: pH 12 / Cooling with ice
2.1: titanium (IV) isopropoxide / diethyl ether / 0.08 h / -78 °C
2.2: 1.5 h / -78 - 20 °C
2.3: 2 h / 20 °C
View Scheme
参考文献
ROTTAPHARM S.P.A.; BORRIELLO, Manuela; ROVATI, Lucio; STASI, Luigi Piero; BUZZI, Benedetta; COLACE, Fabrizio
Patent: WO2012/76063 A1, 2012 ;
WO 2012/076063 A1
