4-溴-5-甲酰基噻唑-2-基氨基甲酸叔丁酯合成路线 （共 2 条）
反应条件
1: (5-bromo-thiazol-2-yl)-carbamic acid tert-butyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran
T=0°C; 0.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=20°C; 12 h;
参考文献
MERCK SHARP and DOHME CORP.; ADDEX PHARMA S.A.; LIVERTON, Nigel, J.; BOLEA, Christelle; CELANIRE, Sylvain; YUNFU, Luo
Patent: WO2012/8999 A2, 2012 ;
Location in patent: Page/Page column 56; 57 ;
WO 2012/008999 A2
反应条件
1: (5-bromo-thiazol-2-yl)-carbamic acid tert-butyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes
T=0°C; 0.833333 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes
12 h;
参考文献
AMGEN INC.
Patent: US2007/173506 A1, 2007 ;
Location in patent: Page/Page column 79 ;
