2-氯-6-(三氟甲基)烟醛合成路线 （共 4 条）
反应条件
1: With diisobutylaluminium hydride in toluene
T=-78°C; Inert atmosphere;
2: With acetic acid in water; toluene
T=0°C; 2 h; Product distribution / selectivity;
参考文献
ARRAY BIOPHARMA INC.; COOK, Adam; HUNT, Kevin, W.; DELISLE, Robert Kirk; ROMOFF, Todd; CLARK, Christopher, T.; KIM, Ganghyeok; CORRETTE, Christopher, P.; DOHERTY, George, A.; BURGESS, Laurence, E.
Patent: WO2010/75200 A1, 2010 ;
Location in patent: Page/Page column 141 ;
WO 2010/075200 A1
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C;
参考文献
Matsufuji, Tetsuyoshi; Shimada, Kousei; Kobayashi, Shozo; Kawamura, Asuka; Fujimoto, Teppei; Arita, Tsuyoshi; Hara, Takashi; Konishi, Masahiro; Abe-Ohya, Rie; Izumi, Masanori; Sogawa, Yoshitaka; Nagai, Youko; Yoshida, Kazuhiro; Takahashi, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 750 - 755
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C
1.2: 0.17 h / -78 - 20 °C
2.1: borane-THF / tetrahydrofuran / 16 h / 20 °C
3.1: pyridinium chlorochromate; silica gel / dichloromethane / 4 h / 20 °C
View Scheme
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; GREUL, Jörg, Nico; MANSFIELD, Darren; FÜSSLEIN, Martin; RIECK, Heiko; RIEDRICH, Matthias; RODEFELD, Lars; KATHER, Kristian; MALSAM, Olga; LÖSEL, Peter; VOERSTE, Arnd; SCHWARZ, Hans-Georg; ILG, Kerstin; GÖRGENS, Ulrich; CARLES, Lionel; COQUERON, Pierrre-Yves; DESBORDES, Philippe; MERESSE, Philippe
Patent: WO2013/64460 A1, 2013 ;
反应条件
1: borane-THF / tetrahydrofuran / 16 h / 20 °C
2: pyridinium chlorochromate; silica gel / dichloromethane / 4 h / 20 °C
View Scheme
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; GREUL, Jörg, Nico; MANSFIELD, Darren; FÜSSLEIN, Martin; RIECK, Heiko; RIEDRICH, Matthias; RODEFELD, Lars; KATHER, Kristian; MALSAM, Olga; LÖSEL, Peter; VOERSTE, Arnd; SCHWARZ, Hans-Georg; ILG, Kerstin; GÖRGENS, Ulrich; CARLES, Lionel; COQUERON, Pierrre-Yves; DESBORDES, Philippe; MERESSE, Philippe
Patent: WO2013/64460 A1, 2013 ;
