1-(3-氯苯基)-1H-1,2,3-噻唑-4-羧酸合成路线 （共 3 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran
T=20°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.
Patent: WO2013/22818 A1, 2013 ;
Location in patent: Paragraph 00329 ;
WO 2013/022818 A1
反应条件
1: sodium nitrite; trifluoroacetic acid; sodium azide / water / |Cooling
2: L-proline; sodium carbonate / dimethyl sulfoxide / 75 °C / |Microwave irradiation
3: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.
Patent: WO2013/22818 A1, 2013 ;
WO 2013/022818 A1
反应条件
1: L-proline; sodium carbonate / dimethyl sulfoxide / 75 °C / |Microwave irradiation
2: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.
Patent: WO2013/22818 A1, 2013 ;
WO 2013/022818 A1
