4-甲氧基-5,6,7,8-四氢-吡啶并[4,3-d]嘧啶合成路线 （共 4 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol
P=760.051 Torr;
参考文献
Wei, Zhi-Liang; O'Mahony, Donogh John Roger; Duncton, Matthew; Kincaid, John; Kelly, Michael G.; Wang, Zhan
Patent: US2008/275037 A1, 2008 ;
Location in patent: Page/Page column 23 ;
反应条件
1.1: sodium methylate / methanol / 16 h / 85 °C
1.2: Cooling with ice
1.3: pH 7
2.1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 1 h / 70 °C
2.2: Cooling with ice
3.1: 2 h / Reflux
4.1: hydrogen / palladium 10 on activated carbon / methanol / 760.05 Torr
View Scheme
参考文献
RENOVIS, INC.
Patent: WO2008/123963 A1, 2008 ;
WO 2008/123963 A1
反应条件
1.1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 1 h / 70 °C
1.2: Cooling with ice
2.1: 2 h / Reflux
3.1: hydrogen / palladium 10 on activated carbon / methanol / 760.05 Torr
View Scheme
参考文献
RENOVIS, INC.
Patent: WO2008/123963 A1, 2008 ;
WO 2008/123963 A1
反应条件
1: 2 h / Reflux
2: hydrogen / palladium 10 on activated carbon / methanol / 760.05 Torr
View Scheme
参考文献
RENOVIS, INC.
Patent: WO2008/123963 A1, 2008 ;
WO 2008/123963 A1
