2,4-二氨基-6-羟甲基蝶啶合成路线 （共 24 条）
反应条件
1: 34 percent / 2 h / 150 °C 2: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 30 min, 2.) CH2Cl2, MeOH, 0 deg C, 2 h 3: 63 percent / NaBH4 / CH2Cl2; propan-2-ol / 0.5 h / -10 °C 4: 77 percent / 1N aq. NaOH / dimethylformamide / 4 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 5 p. 363 - 368
反应条件
1: 63 percent / NaBH4 / CH2Cl2; propan-2-ol / 0.5 h / -10 °C 2: 77 percent / 1N aq. NaOH / dimethylformamide / 4 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 5 p. 363 - 368
反应条件
1: 1.) O3, 2.) Me2S / 1.) CH2Cl2, MeOH, -78 deg C, 30 min, 2.) CH2Cl2, MeOH, 0 deg C, 2 h 2: 63 percent / NaBH4 / CH2Cl2; propan-2-ol / 0.5 h / -10 °C 3: 77 percent / 1N aq. NaOH / dimethylformamide / 4 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 5 p. 363 - 368
反应条件
air; D,L-Cysteine; sodium acetate
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 10 p. 1463 - 1468
反应条件
sodium acetate; boric acid; hydrazine hydrate Reagens 4: Essigsaeure;
反应条件
in phosphate buffer pH=7.8; Irradiation; Product distribution;
参考文献
Photochemistry and Photobiology, , vol. 76, # 5 p. 467 - 472
反应条件
1: Br2, triphenylphosphine / N,N-dimethyl-acetamide / 18 h / 25 °C 2: BaO / N,N-dimethyl-acetamide / 21 h / 45 °C View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
1: Br2, triphenylphosphine / N,N-dimethyl-acetamide / 18 h / 25 °C 2: BaO / N,N-dimethyl-acetamide / 24 h / 55 °C 3: Ac2O / 2.5 h / Heating 4: 94 percent / Et3N / dimethylformamide / 18 h / 25 °C 5: 74 percent / Et3N / dimethylformamide / 73 h / 55 °C 6: 0.25 N aq. NaOH / 1.75 h / 25 °C View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
bromine; triphenylphosphine in N,N-dimethyl acetamide T=25°C; 18 h;
参考文献
KONINKLIJKE PHILIPS ELECTRONICS N.V.
Patent: WO2007/110811 A2, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
1: Br2, triphenylphosphine / N,N-dimethyl-acetamide / 18 h / 25 °C 2: BaO / N,N-dimethyl-acetamide / 24 h / 55 °C View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
