2,4-二氨基-6-羟甲基蝶啶合成路线 （共 24 条）
反应条件
1: 2,4-diamino-6- (hydroxymethyl)pteridine With bromine; triphenylphosphine in various solvent(s) T=20°C; 2: p-(N-methyl)-amino-benzoic acid With N-ethyl-N,N-diisopropylamine in various solvent(s) T=45°C; 30 h; Further stages.;
参考文献
Valiaeva; Bartley; Konno; Coward
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 5146 - 5154
反应条件
1: Br2, triphenylphosphine / N,N-dimethyl-acetamide / 18 h / 25 °C
2: i-Pr2NEt / N,N-dimethyl-acetamide / 25 h / 45 - 50 °C
View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
1: Br2, triphenylphosphine / N,N-dimethyl-acetamide / 18 h / 25 °C
2: BaO / N,N-dimethyl-acetamide / 24 h / 55 °C
3: Ac2O / 2.5 h / Heating
View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
thionyl bromide
T=20°C; 24 h; Neat (no solvent);
参考文献
Marques, Sergio M.; Enyedy, Eva A.; Supuran, Claudiu T.; Krupenko, Natalia I.; Krupenko, Sergey A.; Amelia Santos
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5081 - 5089
