(E)-3-苯基-2-丁烯酸乙酯合成路线 （共 15 条）
反应条件
1: ethanol; nickel catalyst / Hydrogenation
2: aq. NaOH solution
View Scheme
参考文献
Rupe; van Walraven
Helvetica Chimica Acta, 1930 , vol. 13, p. 361,375
反应条件
1: 98 percent / i-PrMgCl / tetrahydrofuran / 0.5 h / -5 °C
2: tetrahydrofuran
3: H2 / Pd/C
View Scheme
参考文献
Kanazawa, Yoshinori; Tsuchiya, Yasunori; Kobayashi, Kazuki; Shiomi, Takushi; Itoh, Jun-Ichi; Kikuchi, Makoto; Yamamoto, Yoshihiko; Nishiyama, Hisao
Chemistry - A European Journal, 2006 , vol. 12, # 1 p. 63 - 71
反应条件
1: diisobutylaluminium hydride / dichloromethane / 0 °C / Inert atmosphere
2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere
3: tris-(dibenzylideneacetone)dipalladium(0); [(R)-methoxy(furyl)BIPHEP]; cesium fluoride / tetrahydrofuran; water / 36 h / 60 °C / Inert atmosphere
View Scheme
参考文献
Zhang, Ping; Le, Hai; Kyne, Robert E.; Morken, James P.
Journal of the American Chemical Society, 2011 , vol. 133, # 25 p. 9716 - 9719
反应条件
1: 98 percent / i-PrMgCl / tetrahydrofuran / 0.5 h / -5 °C
2: tetrahydrofuran
View Scheme
参考文献
Kanazawa, Yoshinori; Tsuchiya, Yasunori; Kobayashi, Kazuki; Shiomi, Takushi; Itoh, Jun-Ichi; Kikuchi, Makoto; Yamamoto, Yoshihiko; Nishiyama, Hisao
Chemistry - A European Journal, 2006 , vol. 12, # 1 p. 63 - 71
反应条件
Multi-step reaction with 2 steps 1.1: diisobutylaluminium hydride / diethyl ether; hexane / 10.33 h / 20 °C / Inert atmosphere; Cooling with ice2.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane; toluene / -25 - -20 °C / Inert atmosphere; Molecular sieve2.2: polymethylhydrosiloxane / 1 h / 20 °C / Inert atmosphere
参考文献
Rahaim, Ronald J.; Maleczka, Robert E. Organic Letters, 2011 , vol. 13, # 4 p. 584 - 587
