7-氨基-4-羟基-2-萘羧酸乙酯合成路线 （共 5 条）
反应条件
sulfuric acid
24 h; Heating / reflux;
参考文献
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
Patent: WO2007/149782 A2, 2007 ;
Location in patent: Page/Page column 19; 21 ;
WO 2007/149782 A2
反应条件
1: (E)-3-(methoxycarbonyl)-4-(3-aminophenyl)but-3-enoic acid With sodium acetate in acetic anhydride
Friedel-Crafts reaction; 0.0833333 h; microwave irradiation;
2: With sulfuric acid in ethanol
24 h; Heating;
3: 1,1'-carbonyldiimidazole With triethylamine in tetrahydrofuran
T=0°C; 3 h; Further stages.;
参考文献
Castellano, Sabrina; Milite, Ciro; Campiglia, Pietro; Sbardella, Gianluca
Tetrahedron Letters, 2007 , vol. 48, # 27 p. 4653 - 4655
反应条件
1: With sodium acetate in acetic anhydride
Friedel-Crafts reaction; 0.0833333 h; microwave irradiation;
2: With sulfuric acid in ethanol
24 h; Heating; Further stages.;
参考文献
Castellano, Sabrina; Milite, Ciro; Campiglia, Pietro; Sbardella, Gianluca
Tetrahedron Letters, 2007 , vol. 48, # 27 p. 4653 - 4655
反应条件
1: (E)-3-(methoxycarbonyl)-4-(3-aminophenyl)but-3-enoic acid With sodium acetate; acetic anhydride
Friedel-Crafts type acylation; 0.0833333 h; Microwave irradiationInert atmosphere;
2: With hydrogenchloride; water
5 h;
3: ethanol regioselective reactionFurther stages;
参考文献
Castellano, Sabrina; Milite, Ciro; Ragno, Rino; Simeoni, Silvia; Mai, Antonello; Limongelli, Vittorio; Novellino, Ettore; Bauer, Ingo; Brosch, Gerald; Spannhoff, Astrid; Cheng, Donghang; Bedford, Mark T.; Sbardella, Gianluca
ChemMedChem, 2010 , vol. 5, # 3 p. 398 - 414
反应条件
1: (E)-3-(methoxycarbonyl)-4-(3-aminophenyl)but-3-enoic acid With sodium acetate; acetic anhydride
Friedel-Crafts type acylation; 0.0833333 h; Microwave irradiationInert atmosphere;
2: With hydrogenchloride; water
5 h;
3: ethanol With sulfuric acid
24 h; RefluxInert atmosphere;
参考文献
Castellano, Sabrina; Milite, Ciro; Ragno, Rino; Simeoni, Silvia; Mai, Antonello; Limongelli, Vittorio; Novellino, Ettore; Bauer, Ingo; Brosch, Gerald; Spannhoff, Astrid; Cheng, Donghang; Bedford, Mark T.; Sbardella, Gianluca
ChemMedChem, 2010 , vol. 5, # 3 p. 398 - 414
