2-溴-1-(4-溴-1,1-联苯-4-基)乙酮合成路线 （共 4 条）
反应条件
bromine in dichloromethane
T=20°C; 48 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; DAS, Sanjoy Kumar; BENNANI, Youssef L.
Patent: WO2011/119853 A1, 2011 ;
Location in patent: Page/Page column 95 ;
反应条件
in methanol; dichloromethane
参考文献
Bigg, Dennis; Pommier, Jacques; Liberatore, Anne-Marie
Patent: US2004/77640 A1, 2004 ;
US 20040077640 A1
反应条件
1: 77 percent / AlCl3 / CS2 / 1 h / Heating
2: 87 percent / bromine / acetic acid
View Scheme
参考文献
Schwab, John M.; Lin, Daniel C. T.
Journal of the American Chemical Society, 1985 , vol. 107, # 21 p. 6046 - 6052
反应条件
copper(ll) bromide in chloroform; ethyl acetate
5 h; Reflux;
参考文献
Roman, Gheorghe; Vlahakis, Jason Z.; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A.
ChemMedChem, 2010 , vol. 5, # 9 p. 1541 - 1555
