2,4-二氯吡啶-3-甲醇合成路线 （共 2 条）
反应条件
1: With sodium tetrahydroborate in ethanol
T=20°C; 1 h;
2: With water; sodium hydrogencarbonate in ethanol
参考文献
JERINI AG; GIBSON, Christoph; SCHNATBAUM, Karsten; TRADLER, Thomas; PFEIFER, Jochen; SCHARN, Dirk; REIMER, Ulf; RICHTER, Uwe; HUMMEL, Gerd; REINEKE, Ulrich; LOCARDI, Elsa; PASCHKE, Matthias
Patent: WO2010/31589 A1, 2010 ;
Location in patent: Page/Page column 49-50 ;
WO 2010/031589 A1
反应条件
1: 2,4-Dichloropyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=-78°C; 1 h;
2: chloroformic acid ethyl ester in tetrahydrofuran; n-heptane; ethylbenzene
T=-78°C; 1 h;
3: With sodium hydrogencarbonate in tetrahydrofuran; n-heptane; ethylbenzene; water
T=-78 - 20°C;
参考文献
ABBOTT HEALTHCARE PRODUCTS B.V.; STOIT, Axel; IWEMA BAKKER, Wouter, I.; COOLEN, Hein K.A.C.; VAN DONGEN, Maria J.P.; LEFLEMME, Nicolas J.-L.D.
Patent: WO2012/4378 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/004378 A1
